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                                脂質體裝備

                                TLEx 罐體式脂質體擠出器

                                蘇州艾特森制藥設備有限公司位于蘇州工業園區,是一家自主研發、專業生產及銷售制藥裝備的科技生產型企業。

                                TLEx 罐體式脂質體擠出器

                                TLEx Tank Liposome Extruder


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                                主要應用

                                ◆阿霉素脂質體 Doxorubicin liposome

                                ◆ 兩性霉素 B 脂質體 Amphotericin B liposome

                                ◆ 紫杉醇脂質體 Paclitaxel liposomes

                                ◆ 奧沙利鉑脂質體 Oxaliplatin liposomes

                                ◆ 伊立替康脂質體 Irinotecan liposome

                                ◆ SiRNA 脂質體 SiRNA liposome

                                ◆ 白蛋白紫杉醇納米粒 Albumin paclitaxel nanoparticles

                                ◆ 核酸類脂質體  Nucleic acid liposome

                                ◆ mRNA脂質體 mRNA  liposome

                                 

                                擠出原理

                                Extrusion Principle

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                                擠出原理圖

                                Extrusion schematic diagram

                                 

                                ◆樣品經過水化形成脂質體后,一般會通過高壓均質或者超聲的方式對樣品進行初步均質處理,處理后樣品粒徑和分布都會有所提高,但往往還不能達到所需要的理想要求。此時,將均質后樣品由下圖中進料口進入,通過高壓氮氣將樣品從濾膜中擠出,擠出后的樣品粒徑和分布都會進一步提高。

                                After the sample is hydrated to form liposomes, the sample is usually homogenized by high-pressure homogenization or ultrasonic wave. After treatment, the particle size and distribution of the sample will be improved, but it can not meet the desired requirements. At this time, the homogenized sample enters through the feed port in the figure below, and the sample is extruded from the filter membrane by high-pressure nitrogen. The particle size and distribution of the extruded sample will be further improved

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                                支撐板

                                Support plate

                                 

                                ◆支撐板和濾板主要起到支撐濾膜的作用。 由于磷脂有一定的相變溫度,所以在擠出之前需要對擠出器夾套通入恒溫水進行預熱至一定溫度(如70℃),且在使用過程中需保持在此溫度。通常的脂質體品種擠出之后粒徑能達到 100nm以下,PDI 能控制在 0.1 以下。

                                The supporting plate and filter plate mainly play the role of supporting the filter membrane. Since the phospholipid has a certain phase transition temperature, it is necessary to preheat the extruder jacket with constant temperature water before extrusion to a certain temperature (such as 70 ℃), which should be maintained in the process of use. After extrusion, the particle size of liposomes can reach below 100nm and PDI can be controlled below 0.1.

                                 

                                ◆動力源:氮氣

                                Power source: nitrogen

                                 

                                技術特征

                                Technical features

                                ◆核心部件  The core components

                                支撐板(SS316L不銹鋼)

                                Support plate (SS316L stainless steel)

                                濾板(SS316L不銹鋼)

                                Filter plate (SS316L stainless steel)

                                濾膜:PC材質(聚碳酸酯)

                                Filter membrane :PC material (polycarbonate)

                                密封系統:PU材質/聚四氟乙烯

                                Sealing system: PU material/polytetrafluoroethylene

                                溫控系統:夾套控溫

                                Temperature control system: jacket temperature  control

                                 

                                ◆技術特點 Technical characteristics

                                所有部件包括“O”型圈,墊圈均通過FDA 認證 

                                All parts including "O" rings, gaskets are FDA approved

                                操作便捷,可重復使用 

                                Easy to operate and reusable

                                嚴格控制產品粒徑,可單次操作或循環操作 

                                Strictly control the particle size of products, single operation or cycle operation

                                裝卸方便,便于清洗和滅菌 

                                Easy loading and unloading, easy cleaning and sterilization

                                所有數據可直接放大 

                                All data can be directly amplified

                                預設壓力保護閥 

                                Preset pressure protection valve

                                可用于高濃度樣品處理 

                                Can be used for high concentration sample processing

                                可放在潔凈室中使用,符合 GMP 標準 

                                Can be used in a clean room, accord with GMP standards

                                 

                                技術參數

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